The concomitant use of opioids with other medications that have an effect on the serotonergic neurotransmitter process has resulted in serotonin syndrome.Promethazine is undoubtedly an H1 receptor blocking agent. Together with its antihistaminic motion, it offers clinically useful sedative and antiemetic effects. Promethazine is very well absorbed

Narcotic analgesics bring about histamine launch, which appears to be responsible for wheals or urticaria in some cases seen at the website of injection on parenteral administration.When medical professionals prescribe codeine-containing medication, they ought to choose the least expensive successful dose to the shortest length of time and should n